Angiogenic agonist polypeptide and application thereof

一种血管生成激动剂多肽及应用

Abstract

本发明涉及药物领域,具体涉及具有血管生成激动剂多肽,能治疗缺血性疾病的多肽。其特征在于,所述多肽的序列为全新序列,具有促进血管生成的作用。用于缺血性脑卒中。本发明的有益效果在于,本发明的序列为GPR124细胞膜表面受体序列蛋白中筛选出的具有血管生成活性的新型小分子多肽,该多肽序列能特异性与整合素结合,具有调节细胞在血管生成过程中粘附和迁移,从而起到治疗缺血性疾病的作用。具有潜在的新药开发价值。
The invention relates to the field of medicine, in particular to an angiogenic agonist polypeptide, capable of treating ischemic diseases. The angiogenic agonist polypeptide is characterized in that a sequence of the polypeptide is a novel sequence having the effect of promoting angiogenesis. The angiogenic agonist polypeptide is useful in ischemic stroke. The invention has the advantages that the sequence is a novel small-molecular polypeptide with angiogenic activity screened from GPR124 cell membrane surface receptor sequence protein, the polypeptide sequence can specifically bind with integrin and has the function of adjusting adhesion and migration of cells during angiogenesis so as to treat ischemic diseases, and the angiogenic agonist polypeptide has potential value in the development of new drugs.

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